W. Wallace Cleland
William Wallace Cleland (often cited as W. W. Cleland) is a University of Wisconsin-Madison biochemistry professor. His research focuses on enzyme reaction mechanism and enzyme kinetics,[1] especially multiple-substrate enzymes. He was elected to the National Academy of Sciences in 1985.[2]
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[edit] Early life and education
Cleland was born in 1930 in Baltimore, Maryland. He received his A.B. from Oberlin College in 1950 and his M.S. and Ph.D. from the University of Wisconsin–Madison in 1953 and 1955, respectively.[3]
[edit] Career
After carrying out postdoctoral research at the University of Chicago he returned to University of Wisconsin–Madison, where he became Assistant Professor in 1959. In 1962 he was promoted to Associate Professor and then Professor in 1966. He became J. Johnson Professor of Biochemistry in 1978, and Steenbock Professor of Chemical Science in 1982.[1]
[edit] Scientific contributions
Cleland is well known for being the first to utilize dithiothreitol for the reduction of disulfide bonds in proteins. The compound is therefore often called Cleland's reagent.[4] His research interests focus on the use of enzyme kinetics to deduce enzyme mechanics, primarily those mechanisms involved in phosphoryl and acyl transfers.[3] He was a pioneer in the kinetic and mechanistic study of enzymes that utilize more than one substrate.[5]
[edit] Notable publications
[edit] Books
- Enzyme Kinetics and Mechanism (2007) Paul F. Cook and W.W. Cleland. Garland Science (ISBN 978-0815341406)
[edit] Awards and recognition
- 1985 - Elected to the National Academy of Sciences
- 1986 - Fulbright Senior Scholar Award[3]
- 1990 - Merck Award (American Society for Biochemistry and Molecular Biology)[3]
- 1993 - Alfred Bader Award in Bioinorganic or Bioorganic Chemistry (American Chemical Society)[3]
- 1995 - Repligen Award (Biological Division of the American Chemical Society)[3]
- 1999 - Stein and Moore Award (Protein Society)[3]
[edit] References
- ^ a b Academic home page
- ^ "Enzyme Kinetics and Mechanism - The authors". http://mrcgp.net/textbooks/0815341407.asp?type=authors. Retrieved 24 January 2010.
- ^ a b c d e f g J. Biol. Chem. biographical article
- ^ Cleland, W.W. (April 1964). "Dithiothreitol, A New Protective Reagent for SH Groups". Biochemistry 3 (4): 480–2. doi:10.1021/bi00892a002. PMID 14192894.
- ^ Cook, Paul; Cleland, William Wallace (2007). Enzyme kinetics and mechanism. London: Garland Science. ISBN 978-0-8153-4140-6.
