WAY-208,466

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WAY-208,466
WAY-208466-structure.png
Systematic (IUPAC) name
N'-[(2Z)-4-(2,4-dichlorophenyl)-3-(2-methylpropyl)-1,3-thiazol-2(3H)-ylidene]-2-(pyrazin-2-yloxy)acetohydrazide
Clinical data
Legal status
?
Identifiers
CAS number ?
ATC code None
PubChem CID 11820788
ChemSpider 9995440
ChEMBL CHEMBL571858
Chemical data
Formula C19H19Cl2N5O2S 
Mol. mass 452.36 g/mol

WAY-208,466 is a potent and highly selective full agonist of the 5-HT6 receptor.[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.[1] Animal studies have shown that WAY-208,466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.[1][2]

See also[edit]

References[edit]

  1. ^ a b c Schechter LE, Lin Q, Smith DL, et al. (May 2008). "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology 33 (6): 1323–35. doi:10.1038/sj.npp.1301503. PMID 17625499. 
  2. ^ Carr GV, Schechter LE, Lucki I (March 2010). "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology 213 (2–3): 499–507. doi:10.1007/s00213-010-1798-7. PMC 2910165. PMID 20217056.