WAY-213,613

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WAY-213,613
WAY-213,613 structure.png
Systematic (IUPAC) name
(2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
Clinical data
Legal status
?
Identifiers
CAS number 868359-05-1
ATC code ?
PubChem CID 11531745
ChEMBL CHEMBL1628669
Chemical data
Formula C16H13BrF2N2O4 
Mol. mass 415.186 g/mol
 YesY (what is this?)  (verify)

WAY-213,613 is a drug which acts as a reuptake inhibitor for the glutamate transporter subtype EAAT2, selective over other glutamate transporter subtypes and highly selective over metabotropic and ionotropic glutamate receptors.[1] It is used in scientific research into the function of the glutamate transporters.[2]

References[edit]

  1. ^ Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A et al. (2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2". Molecular Pharmacology 68 (4): 974–82. doi:10.1124/mol.105.012005. PMID 16014807. 
  2. ^ Karatas-Wulf, U; Koepsell, H; Bergert, M; Sönnekes, S; Kugler, P (2009). "Protein kinase C-dependent trafficking of glutamate transporters excitatory amino acid carrier 1 and glutamate transporter 1b in cultured cerebellar granule cells". Neuroscience 161 (3): 794–805. doi:10.1016/j.neuroscience.2009.04.017. PMID 19364521.