WDR12
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| WD repeat domain 12 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | WDR12; FLJ10881; FLJ12719; FLJ12720; YTM1 | ||||||||||||
| External IDs | MGI: 1927241 HomoloGene: 10098 GeneCards: WDR12 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55759 | 57750 | |||||||||||
| Ensembl | ENSG00000138442 | ENSMUSG00000026019 | |||||||||||
| UniProt | Q9GZL7 | Q4V9X1 | |||||||||||
| RefSeq (mRNA) | NM_018256 | NM_021312 | |||||||||||
| RefSeq (protein) | NP_060726 | NP_067287 | |||||||||||
| Location (UCSC) | Chr 2: 203.74 – 203.88 Mb |
Chr 1: 60.13 – 60.16 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Ribosome biogenesis protein WDR12 is a protein that in humans is encoded by the WDR12 gene.[1][2][3]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The function of this protein is not known.[3]
[edit] References
- ^ Holzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D (Aug 2005). "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation". J Cell Biol 170 (3): 367–78. doi:10.1083/jcb.200501141. PMC 2171466. PMID 16043514. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171466.
- ^ Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D (May 2007). "Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit". Mol Cell Biol 27 (10): 3682–94. doi:10.1128/MCB.00172-07. PMC 1899993. PMID 17353269. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1899993.
- ^ a b "Entrez Gene: WDR12 WD repeat domain 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55759.
[edit] Further reading
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Nal B, Mohr E, Silva MI, et al. (2002). "Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain.". Genomics 79 (1): 77–86. doi:10.1006/geno.2001.6682. PMID 11827460.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133617.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Higa LA, Wu M, Ye T, et al. (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
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