WDR4

WD repeat domain 4
Identifiers
Symbols	WDR4; TRM82
External IDs	OMIM: 605924 MGI: 1889002 HomoloGene: 32422 GeneCards: WDR4 Gene
Gene Ontology Molecular function • protein binding • tRNA (guanine-N7-)-methyltransferase activity Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • tRNA modification Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10785	57773
Ensembl	ENSG00000160193	ENSMUSG00000024037
UniProt	P57081	Q9EP82
RefSeq (mRNA)	NM_018669.4	NM_021322.2
RefSeq (protein)	NP_061139.2	NP_067297.2
Location (UCSC)	Chr 21: 44.26 – 44.3 Mb	Chr 17: 31.63 – 31.66 Mb
PubMed search	[1]	[2]

tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme that in humans is encoded by the WDR4 gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Michaud J, Kudoh J, Berry A, et al. (2001). "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein.". Genomics 68 (1): 71–9. doi:10.1006/geno.2000.6258. PMID 10950928. 
• Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370335. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1142581. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526728. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.