WFIKKN1

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WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Protein WFIKKN1 PDB 2ddi.png
PDB rendering based on 2ddi.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols WFIKKN1 ; C16orf12; RJD2; WFDC20A; WFIKKN
External IDs OMIM608021 MGI2670967 HomoloGene14244 GeneCards: WFIKKN1 Gene
RNA expression pattern
PBB GE WFIKKN1 gnf1h01263 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 117166 215001
Ensembl ENSG00000127578 ENSMUSG00000071192
UniProt Q96NZ8 Q8R0S6
RefSeq (mRNA) NM_053284 NM_001100454
RefSeq (protein) NP_444514 NP_001093924
Location (UCSC) Chr 16:
0.68 – 0.68 Mb
Chr 17:
25.88 – 25.88 Mb
PubMed search [1] [2]

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that in humans is encoded by the WFIKKN1 gene.[1][2][3]

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.[3]

References[edit]

  1. ^ Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A 98 (7): 3705–9. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388. 
  2. ^ Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. 
  3. ^ a b "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1". 

Further reading[edit]