Music played on WKNH includes alternative rock, indie rock, world music, jazz, reggae, hip hop, hardcore, metal, folk, and other eclectic selections typical of college radio stations. Longform programming includes shows news and commentary shows such as Pacifica's Democracy Now. The station's DJ content is predominantly student and local community member-based, with basic DJ qualifications being "if you are a Keene State College student, faculty member, or a member of the Keene community within driving distance [to the station]". The station airs live performances of plays, bands and poetry on a regular basis, which is posted on the station's website previous to the events. WKNH began streaming its programming live on the internet from its wknh.org website on January 1, 2006.
In November 2012, WKNH released a compilation of rare and unreleased acoustic tracks called Give Some to the Starving Artist featuring songs from Max Bemis of Say Anything, Owen, The Civil Wars, and Someone Still Loves You Boris Yeltsin among others. All proceeds from the compilation went towards the funding and continued operation of the Keene arts venue/collective The Starving Artist. The compilation also featured songs from local artists along with album art created by graphic designers from The Keene State Equinox.