WNT10A

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Wingless-type MMTV integration site family, member 10A
Identifiers
Symbols WNT10A ; OODD; SSPS; STHAG4
External IDs OMIM606268 MGI108071 HomoloGene22525 GeneCards: WNT10A Gene
Orthologs
Species Human Mouse
Entrez 80326 22409
Ensembl ENSG00000135925 ENSMUSG00000026167
UniProt Q9GZT5 P70701
RefSeq (mRNA) NM_025216 NM_009518
RefSeq (protein) NP_079492 NP_033544
Location (UCSC) Chr 2:
219.75 – 219.76 Mb
Chr 1:
74.79 – 74.8 Mb
PubMed search [1] [2]

Wnt-10a is a protein that in humans is encoded by the WNT10A gene.[1][2][3]

Function[edit]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.[1]

Clinical significance[edit]

WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.[1]

Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome[4] and hypodontia.[5]

References[edit]

  1. ^ a b c "Entrez Gene: wingless-type MMTV integration site family". 
  2. ^ Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055. 
  3. ^ Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de Mazancourt P, Megarbane A (October 2007). "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia". Am. J. Hum. Genet. 81 (4): 821–8. doi:10.1086/520064. PMC 1973944. PMID 17847007. 
  4. ^ Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Röpke A (July 2009). "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes". Am. J. Hum. Genet. 85 (1): 97–105. doi:10.1016/j.ajhg.2009.06.001. PMC 2706962. PMID 19559398. 
  5. ^ van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, Ploos van Amstel HK (May 2012). "Mutations in WNT10A are present in more than half of isolated hypodontia cases". J. Med. Genet. 49 (5): 327–31. doi:10.1136/jmedgenet-2012-100750. PMID 22581971. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.