WNT10B

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Wingless-type MMTV integration site family, member 10B
Identifiers
Symbols WNT10B ; SHFM6; WNT-12
External IDs OMIM601906 MGI108061 HomoloGene20721 GeneCards: WNT10B Gene
RNA expression pattern
PBB GE WNT10B 206213 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7480 22410
Ensembl ENSG00000169884 ENSMUSG00000022996
UniProt O00744 P48614
RefSeq (mRNA) NM_003394 NM_011718
RefSeq (protein) NP_003385 NP_035848
Location (UCSC) Chr 12:
49.36 – 49.37 Mb
Chr 15:
98.77 – 98.78 Mb
PubMed search [1] [2]

Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene.[1][2][3][4]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[4]

References[edit]

  1. ^ Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776. 
  2. ^ Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937. 
  3. ^ Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319. 
  4. ^ a b "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B". 

Further reading[edit]