WNT2B

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Wingless-type MMTV integration site family, member 2B
Identifiers
Symbols WNT2B ; WNT13
External IDs OMIM601968 MGI1261834 HomoloGene22526 GeneCards: WNT2B Gene
RNA expression pattern
PBB GE WNT2B 206458 s at tn.png
PBB GE WNT2B 206459 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7482 22414
Ensembl ENSG00000134245 ENSMUSG00000027840
UniProt Q93097 O70283
RefSeq (mRNA) NM_001291880 NM_009520
RefSeq (protein) NP_001278809 NP_033546
Location (UCSC) Chr 1:
113.01 – 113.07 Mb
Chr 3:
104.94 – 104.96 Mb
PubMed search [1] [2]

Protein Wnt-2b is a protein that in humans is encoded by the WNT2B gene.[1][2][3]

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis.

This gene produces two alternative transcript variants.[3]

References[edit]

  1. ^ Katoh M, Hirai M, Sugimura T, Terada M (Oct 1996). "Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family". Oncogene 13 (4): 873–6. PMID 8761309. 
  2. ^ Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J (Sep 2000). "Alternative splicing of the WNT-2B/WNT-13 gene". Biochem Biophys Res Commun 275 (1): 209–16. doi:10.1006/bbrc.2000.3252. PMID 10944466. 
  3. ^ a b "Entrez Gene: WNT2B wingless-type MMTV integration site family, member 2B". 

Further reading[edit]