WNT3

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Wingless-type MMTV integration site family, member 3
Identifiers
Symbols WNT3 ; INT4
External IDs OMIM165330 MGI98955 HomoloGene22527 ChEMBL: 6079 GeneCards: WNT3 Gene
RNA expression pattern
PBB GE WNT3 221455 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7473 22415
Ensembl ENSG00000108379 ENSMUSG00000000125
UniProt P56703 P17553
RefSeq (mRNA) NM_030753 NM_009521
RefSeq (protein) NP_110380 NP_033547
Location (UCSC) Chr 17:
44.84 – 44.91 Mb
Chr 11:
103.77 – 103.82 Mb
PubMed search [1] [2]

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.[2]

References[edit]

  1. ^ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403. 
  2. ^ a b "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3". 

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