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Wingless-type MMTV integration site family, member 5A
Symbols WNT5A ; hWNT5A
External IDs OMIM164975 MGI98958 HomoloGene20720 GeneCards: WNT5A Gene
Species Human Mouse
Entrez 7474 22418
Ensembl ENSG00000114251 ENSMUSG00000021994
UniProt P41221 P22725
RefSeq (mRNA) NM_001256105 NM_001256224
RefSeq (protein) NP_001243034 NP_001243153
Location (UCSC) Chr 3:
55.5 – 55.52 Mb
Chr 14:
28.5 – 28.53 Mb
PubMed search [1] [2]

Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling lipid modified glycoproteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.[3] This gene is a member of the WNT gene family. The WNT5A is highly expressed in the dermal papilla of depilated skin. It encodes a protein showing 98%, 98%, and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.[2]


  1. ^ Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV (Feb 1994). "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21". Genomics 18 (2): 249–60. doi:10.1006/geno.1993.1463. PMID 8288227. 
  2. ^ a b "Entrez Gene: WNT5A wingless-type MMTV integration site family, member 5A". 
  3. ^ Bhatt PM, Malgor R (September 2014). "Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders". Atherosclerosis 237 (1): 155–62. doi:10.1016/j.atherosclerosis.2014.08.027. PMID 25240110. 

Further reading[edit]

  • "Wnt5a". Signaling Gateway Molecule Pages.