The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem.267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID10866835.
Saitoh T, Katoh M (2003). "Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells". Int. J. Mol. Med.10 (3): 345–9. doi:10.3892/ijmm.10.3.345. PMID12165812.
Mangioni S, Viganò P, Lattuada D, et al. (2005). "Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor". J. Clin. Endocrinol. Metab.90 (9): 5349–55. doi:10.1210/jc.2005-0272. PMID15972578.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.