WNT7A

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Wingless-type MMTV integration site family, member 7A
Identifiers
Symbol WNT7A
External IDs OMIM601570 MGI98961 HomoloGene20969 GeneCards: WNT7A Gene
RNA expression pattern
PBB GE WNT7A 210248 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7476 22421
Ensembl ENSG00000154764 ENSMUSG00000030093
UniProt O00755 P24383
RefSeq (mRNA) NM_004625 NM_009527
RefSeq (protein) NP_004616 NP_033553
Location (UCSC) Chr 3:
13.86 – 13.92 Mb
Chr 6:
91.36 – 91.41 Mb
PubMed search [1] [2]

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.[1][2][3]

Function[edit]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.[3]

References[edit]

  1. ^ Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y (Dec 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet 74 (1–2): 149–52. doi:10.1159/000134404. PMID 8893824. 
  2. ^ Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL (Jun 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene 189 (1): 25–9. doi:10.1016/S0378-1119(96)00808-6. PMID 9161407. 
  3. ^ a b "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A". 

Further reading[edit]