WNT7B

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Wingless-type MMTV integration site family, member 7B
Identifiers
Symbol WNT7B
External IDs OMIM601967 MGI98962 HomoloGene22531 GeneCards: WNT7B Gene
Orthologs
Species Human Mouse
Entrez 7477 22422
Ensembl ENSG00000188064 ENSMUSG00000022382
UniProt P56706 P28047
RefSeq (mRNA) NM_058238 NM_001163633
RefSeq (protein) NP_478679 NP_001157105
Location (UCSC) Chr 22:
46.32 – 46.37 Mb
Chr 15:
85.54 – 85.58 Mb
PubMed search [1] [2]

Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene.[1][2][3][4]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.[4]

References[edit]

  1. ^ Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (Jun 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res 54 (10): 2615–21. PMID 8168088. 
  2. ^ van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenet Cell Genet 77 (3–4): 288–9. doi:10.1159/000134600. PMID 9284940. 
  3. ^ Kirikoshi H, Sekihara H, Katoh M (Sep 2001). "Molecular cloning and characterization of human WNT7B". Int J Oncol 19 (4): 779–83. PMID 11562755. 
  4. ^ a b "Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B". 

Further reading[edit]