WNT9A

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Wingless-type MMTV integration site family, member 9A
Identifiers
Symbols WNT9A ; WNT14
External IDs OMIM602863 MGI2446084 HomoloGene20722 GeneCards: WNT9A Gene
Orthologs
Species Human Mouse
Entrez 7483 216795
Ensembl ENSG00000143816 ENSMUSG00000000126
UniProt O14904 Q8R5M2
RefSeq (mRNA) NM_003395 NM_139298
RefSeq (protein) NP_003386 NP_647459
Location (UCSC) Chr 1:
228.11 – 228.14 Mb
Chr 11:
59.31 – 59.33 Mb
PubMed search [1] [2]

Protein Wnt-9a is a protein that in humans is encoded by the WNT9A gene.[1][2]

Wnt14 and 15 have since been renamed as Wnt9A and 9B. [3]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.[2]

References[edit]

  1. ^ Bergstein I, Eisenberg LM, Bhalerao J, Jenkins NA, Copeland NG, Osborne MP, Bowcock AM, Brown AM (Mar 1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749. 
  2. ^ a b "Entrez Gene: WNT9A wingless-type MMTV integration site family, member 9A". 
  3. ^ http://www.stanford.edu/~rnusse/wntgenes/vertwnt.html

Further reading[edit]