WQME offers several nationally syndicated programs, including New Life Live!, Family Life Today, and CBH Viewpoint. The station also offers Hey Howard, Soul 2 Soul, Direct Connection, and Homecoming Radio. Other programs include After Midnight, a program for young adults; Talk'N Sports with Dave Edwards, featuring interviews with local athletes and coaches; and Consider this with Big Joe Clark, a show focused on personal finance and the economy.
WQME's staff includes General Manager Donald Boggs and Program Director Matt Rust, who also hosts the Morning Show on weekday mornings. Other staff include Jerry Morton, engineer; Norma Armogum, certified traffic director; and Becky Melson, bookkeeper.