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Werner helicase interacting protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols WRNIP1 ; RP11-420G6.2; WHIP; bA420G6.2
External IDs OMIM608196 MGI1926153 HomoloGene10592 GeneCards: WRNIP1 Gene
RNA expression pattern
PBB GE WRNIP1 218015 s at tn.png
More reference expression data
Species Human Mouse
Entrez 56897 78903
Ensembl ENSG00000124535 ENSMUSG00000021400
UniProt Q96S55 Q91XU0
RefSeq (mRNA) NM_020135 NM_030215
RefSeq (protein) NP_064520 NP_084491
Location (UCSC) Chr 6:
2.77 – 2.79 Mb
Chr 13:
32.8 – 32.82 Mb
PubMed search [1] [2]

ATPase WRNIP1 is an enzyme that in humans is encoded by the WRNIP1 gene.[1][2]

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.[2]


WRNIP1 has been shown to interact with Werner syndrome ATP-dependent helicase.[1]


  1. ^ a b Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T (Jun 2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally". J Biol Chem 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316. 
  2. ^ a b "Entrez Gene: WRNIP1 Werner helicase interacting protein 1". 

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