WSKO signed on in 1946 as WNDR. It was the most popular Top 40-format station in the area during the 1960s. The studio and 5000-watt transmitter were located on Andrews Road in DeWitt, a Syracuse suburb. During the 1950s, the station began its run as a popular music station after beginning as a Mutual Broadcasting System affiliate. Among its 1950s-era staffers was character actor and Golden Globe nominee Aldo Ray, who worked there in 1956 during an extended break in his film career; a publicity photo of him taken at the station surivives and is reproduced on a station tribute website. During the station's heyday in the late 1950s and 1960s, personalities who would later achieve success in major markets including Bud Ballou, Peter Cavanaugh, Bob Shannon and Joey Reynolds were among the notable disc jockeys that worked at WNDR.
Logo as ESPN Radio 1260, used from 2001 until 2010
During the 1990s and early 2000s, the station struggled. It adopted the WNSS callsign in 1996, after dropping a country music format in favor of all-news under the branding of "W-News". After a brief and ill-fated 2000 change to an all-comedy radio format, the station finally settled on a mostly straight satellite feed from the ESPN Radio network, including ESPN's MLB and NBA broadcasts. The station during most of this period was the flagship station of the Syracuse Orange along with sister station WAQX, until WTKW acquired the rights in 2007. The station was also the home of the Syracuse Chiefs from 2010 to 2012 and the Syracuse Crunch from 2010 to 2013.
WSKO currently carries one local weekday program, Bud and the Manchild, which was previously heard on WHEN, hosted by Bud Poliquin and Jim Lerch, who joined WSKO in May 2010, weekdays 10am-12noon. Former local programs include: On the Block with Brent Axe, 2-6pm. heard on WHEN until early 2009. Axe's program was unaffected by the station's March 2010 programming changes, with the exception of an expansion by one hour.The Danny Parkins Show, hosted by Danny Parkins was added for the 12noon-2pm weekday shift on June 1, 2010. In March 2011, Parkins left WSKO to take a job at KCSP 610 Sports Radio in Kansas City MO. Midday with Mike Lindsley took over the mid-day slot on WSKO 12noon-2pm until the end of 2012, when the show became The Afternoon Drive after the departure of Brent Axe. In late Marck 2013, Lindsley left WSKO to take a job at WTMM 104.5 The Team in Albany, NY.