WTAP (gene)

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Wilms tumor 1 associated protein
Identifiers
Symbols WTAP ; DKFZp686F20131; KIAA0105; MGC3925
External IDs OMIM605442 MGI1926395 HomoloGene68422 GeneCards: WTAP Gene
RNA expression pattern
PBB GE WTAP 210285 x at tn.png
PBB GE WTAP 203137 at tn.png
PBB GE WTAP gnf1h04654 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9589 60532
Ensembl ENSG00000146457 ENSMUSG00000060475
UniProt Q15007 Q9ER69
RefSeq (mRNA) NM_001270531 NM_001113532
RefSeq (protein) NP_001257460 NP_001107004
Location (UCSC) Chr 6:
160.15 – 160.18 Mb
Chr 17:
12.97 – 12.99 Mb
PubMed search [1] [2]

Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene.[1][2][3]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.[3]

Interactions[edit]

WTAP (gene) has been shown to interact with WT1.[2]

References[edit]

  1. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527. 
  2. ^ a b Little NA, Hastie ND, Davies RC (Oct 2000). "Identification of WTAP, a novel Wilms' tumour 1-associating protein". Hum Mol Genet 9 (15): 2231–9. doi:10.1093/oxfordjournals.hmg.a018914. PMID 11001926. 
  3. ^ a b "Entrez Gene: WTAP Wilms tumor 1 associated protein". 

Further reading[edit]