WWP1

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WW domain containing E3 ubiquitin protein ligase 1
Protein WWP1 PDB 1nd7.png
PDB rendering based on 1nd7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols WWP1 ; AIP5; Tiul1; hSDRP1
External IDs OMIM602307 HomoloGene21385 GeneCards: WWP1 Gene
RNA expression pattern
PBB GE WWP1 212637 s at tn.png
PBB GE WWP1 212638 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11059 107568
Ensembl ENSG00000123124 ENSMUSG00000041058
UniProt Q9H0M0 Q8BZZ3
RefSeq (mRNA) NM_007013 NM_001276292
RefSeq (protein) NP_008944 NP_001263221
Location (UCSC) Chr 8:
87.35 – 87.49 Mb
Chr 4:
19.61 – 19.71 Mb
PubMed search [1] [2]

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.[1][2][3]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.[3]

Interactions[edit]

WWP1 has been shown to interact with KLF2,[4] Reticulon 4[5] and CPSF6.[6]

References[edit]

  1. ^ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (June 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421. 
  2. ^ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (July 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol Cell Neurosci 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693. 
  3. ^ a b "Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1". 
  4. ^ Conkright, M D; Wani M A, Lingrel J B (August 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. (United States) 276 (31): 29299–306. doi:10.1074/jbc.M103670200. ISSN 0021-9258. PMID 11375995. 
  5. ^ Qin, Haina; Pu Helen X, Li Minfen, Ahmed Sohail, Song Jianxing (Dec 2008). "Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration". Biochemistry (United States) 47 (51): 13647–58. doi:10.1021/bi8017976. PMID 19035836. 
  6. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]