WW domain-containing transcription regulator protein 1 is a protein that in humans is encoded by the WWTR1gene. It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex.
^Howell M, Borchers C, Milgram SL (Jun 2004). "Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription". J Biol Chem279 (25): 26300–6. doi:10.1074/jbc.M401070200. PMID15096513.
Park KS, Whitsett JA, Di Palma T, et al. (2004). "TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.". J. Biol. Chem.279 (17): 17384–90. doi:10.1074/jbc.M312569200. PMID14970209.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.