WWTR1

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WW domain containing transcription regulator 1
Identifiers
Symbols WWTR1 ; TAZ
External IDs OMIM607392 MGI1917649 HomoloGene9159 GeneCards: WWTR1 Gene
RNA expression pattern
PBB GE WWTR1 202132 at tn.png
PBB GE WWTR1 202134 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25937 97064
Ensembl ENSG00000018408 ENSMUSG00000027803
UniProt Q9GZV5 Q9EPK5
RefSeq (mRNA) NM_001168278 NM_001168281
RefSeq (protein) NP_001161750 NP_001161753
Location (UCSC) Chr 3:
149.24 – 149.45 Mb
Chr 3:
57.46 – 57.58 Mb
PubMed search [1] [2]

WW domain-containing transcription regulator protein 1 is a protein that in humans is encoded by the WWTR1 gene.[1][2][3] It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex.


References[edit]

  1. ^ Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB (Feb 2001). "TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins". EMBO J 19 (24): 6778–91. doi:10.1093/emboj/19.24.6778. PMC 305881. PMID 11118213. 
  2. ^ Howell M, Borchers C, Milgram SL (Jun 2004). "Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription". J Biol Chem 279 (25): 26300–6. doi:10.1074/jbc.M401070200. PMID 15096513. 
  3. ^ "Entrez Gene: WWTR1 WW domain containing transcription regulator 1". 

Further reading[edit]