WYEP-FM, which has always been an independent radio station began broadcasting on April 30, 1974 on 91.5 MHz/Channel 218. Prior to using its own frequency, the Pittsburgh Community Broadcasting Corporation (the licensee which was incorporated in 1972 solely for the purpose of building and operating a community based, non-commercial radio station) produced three hourly music and public affairs programs under agreement with WDUQ, Pittsburgh (formerly owned by Duquesne University, 90.5 MHz). The programs scheduled at 4 p.m. provided an example of the content WYEP would broadcast. The radio station studios were constructed by volunteers. It was located in the South Oakland area of Pittsburgh, 4 Cable Place, in a former police horse stable. In its early days, it was principally operated by volunteers knowledgeable in music or an area of public affairs. In 1982, after a period when the station was off the air, WYEP-FM moved to 91.3 MHz/Channel 217 and upgraded their signal to 18 kW. Transmission facilities were moved from atop the Cathedral of Learning on the University of Pittsburgh campus to a tower above the Monongahela River near Hazelwood. In 1987, the station reorganized and relocated their broadcast facility to the campus of Chatham University in Pittsburgh's East End. In 1994 the station moved to Birmingham Place on the South Side of Pittsburgh. In early 2006, the station began broadcasting from the new WYEP Community Broadcast Center, located in the Bedford Square section of Pittsburgh's South Side. In September 2006, the WYEP Community Broadcast Center received a LEED-NC Silver rating, making it environmentally friendly and "the first green station in the nation" .
WYEP is a National Public Radio member and broadcasts programs produced by the Pacifica Foundation among other sources.