|Wadjmose in hieroglyphs|
He is likely to have been born a few years before his father ascended the throne. He had a brother named Amenmose; it is disputed who their mother was. If they were born to Queen Ahmose, they were full brothers of Hatshepsut and Neferubity. On the other hand Wadjmose may have been the son of Queen Mutnofret and thus a full brother of Thutmose II. 
Wadjmose is depicted in the El-Kab tomb of himself and Amenmose's tutor Paheri (de/es), as sitting on Paheri's lap. He is thought to have predeceased his father. Wadjmose and another prince named Ramose were mentioned in the Theban funerary chapel of Thutmose I where Queen Mutnofret is also included. This chapel may have been erected during the reign of Thutmose II between the places where later the mortuary temple of Thutmose IV and the Ramesseum were built. A statue of Mutnofret was found here, making it likely that she was his mother.