Xiaodong Wang (simplified Chinese: 王晓东; traditional Chinese: 王曉東; pinyin: Wāng Xiǎodōng, born 1963) is a Chinese-born American biochemist best known for his work with cytochrome c. His laboratory developed an in-vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (Apaf-1). These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis.
Wang is a member of United States National Academy of Sciences and the Howard Hughes Medical Institute. Currently he is a professor at National Institute of Biological Sciences, Beijing.
Honors & awards
- 2007, Richard Lounsbery Award, from the National Academy of Sciences, USA
- 2006, Shaw Prize, from the Shaw Foundation
- 2004, NAS Award in Molecular Biology
- 2002, Hackerman Award, from the Welch Foundation
- 2001, Paul Marks Prize, from the Memorial Sloan-Kettering Cancer Center
- 2000, Eli Lilly Award in Biological Chemistry, from American Chemical Society
- Zagorski, N. (2006). "Profile of Xiaodong Wang". Proceedings of the National Academy of Sciences 103 (1): 7–9. doi:10.1073/pnas.0509187103. PMC 1324996. PMID 16380419.
- "Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.Cell. 1997 Aug 8;90(3):405-13.". 1997-08-08. Retrieved 2009-02-09.
- "The Shaw Prize". The Shaw Prize. 2006-06-21. Retrieved 2007-08-01.
- Xiaodong Wang, Ph.D. Lab Research Profile