Weber–Christian disease (also known as "Idiopathic Relapsing febrile non-suppurative panniculitis") is a cutaneous condition characterized by recurrent subcutaneous nodules that heal with depression of the overlying skin.
It is type of panniculitis. It is a rare disease seen in females 30-60 years of age. It is a recurring inflammation of fatty layers of tissue present beneath the skin. Clinical course is characterised by exacerbations and remissions. Lesions are bilaterally symmetrical and are usually seen in the lower legs.
^F. P. Weber. A case of relapsing non-suppurative nodular panniculitis, showing phagocytosis of subcutaneous fat-cells by macrophages. British Journal of Dermatology and Syphilis, Oxford, 1925, 37: 301-311. doi:10.1111/j.1365-2133.1925.tb10003.x