To middle of the 18th century Wefensleben is a pure farmer village. In the district available mineral resources influenced the evolution of the place.
With the discovery of a coal seam in 1741 the coal mining begans. Until 1825 coal was won in up to 12 shafts. From 1809 the Zechenhaus was the seat of the Eastphalian mountain and hut administration and from 1815 up to 1843 of the mountain and hut administration of the government district of Magdeburg.
Between 1750 and 1900 3 quarries were operated to produce sandstone blocks as building material for many sacral and profane buildings in Central Germany.
In the 70's of the 20th century several Plattenbauten were build in the village and Wefensleben became a sleep and living place for the attendants of the Helmstedt–Marienborn border crossing and their families. At this time many members of the Stasi moved to Wefensleben especially attendants of the Passkontrolleinheit (PKE) a division of the former Eastern Germany secret service who worked at the border crossing.