Her works include the plays Sin and Schoolgirl Figure, both of which premiered at Chicago's Goodman Theatre and were directed by David Petrarca. The House of Yes, which premiered in San Francisco at the Magic Theatre and was the theatre's second-longest running show, became an award-winning film by the same name starring Parker Posey and earned a Special Jury Award at the Sundance Film Festival. Other works include Things Being What They Are, and a musical How to Make an Apple Pie and See the World, which is based on Marjorie Priceman's book.
Her play Juvenilia, a comic drama about college students "attempting to find love", premiered off-Broadway at Playwrights Horizons, as did her play The Water Children, both directed by longtime collaborator Petrarca, which has also been seen at Los Angeles’ Matrix Theater where it was cited as "the most challenging political play of 1998" by the L.A. Weekly and earned six L.A. Drama Critics Circle nominations. Things Being What They Are premiered at the Seattle Repertory Theatre and was then seen at Steppenwolf in Chicago in 2003 where its sold-out run was extended twice. The House of Yes has been performed at Soho Repertory Theatre, at the Maxim Gorki Theater in Berlin and at The Gate Theater in London, where it was published in Plays International. Her play THRASH, about skateboarding, was invited to the 2005 National Playwrights Conference. She has been a guest professor at Northwestern University’s film and theater departments. Her prose appeared in Poetry magazine’s 2006 humor issue.
MacLeod's latest play, Find and Sign, premiered at Pioneer Theatre Company in Salt Lake City, Utah, January 13–28, 2012. Set in the New York City music industry (with a slight nod to Othello), Find and Sign is about a bumpy romance between an on-the-rise young record executive and an idealistic public school teacher.
She is married to Read Baldwin and has two sons: Foss and Avery Baldwin. They live in Gambier, Ohio.
- U.S. Public Records Index, Vol 1 (Provo, UT: Ancestry.com Operations, Inc.), 2010.
- "Wendy MacLeod, James Michael Playwright-in-Residence". Kenyon College. Retrieved 2007-02-08.
- "The A.C.T. Young Conservatory Tackles Controversial, and Hysterical, Play by the Author of The House of Yes". American Conservatory Theater. Retrieved 2007-02-08.
- MacLeod, Wendy. "Wendy MacLeod: Juvenilia". Retrieved 2007-03-03.