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Weskoppies is a public psychiatric hospital in Pretoria, Gauteng. It is situated to the west of the city centre and was built on the site of the old botanical gardens.
The hospital is used by the University of Pretoria and the University of Limpopo, amongst others, as a teaching hospital.
In 1892 the first psychiatric institution in the Zuid-Afrikaansche Republiek, the Krankzinnigengesticht, was established in 1892, later being renamed as the Weskoppies Hospital.