On October 21, 2010, the Mustangs played the Chinese national women's hockey team. The game ended in a 2-2 tie as Katie Dillon notched both goals. From January 29, 2011 to February 6, 2011, Katie Dillon led the OUA with a four game point scoring streak in which she registered four goals. On February 11, 2011, Mustangs captain Ellie Seedhouse scores a goal in her final CIS game as Western fell to the Brock Badgers by a 5-1 mark.
Two Mustangs rookies were named to the 2012 OUA All-Rookie team. Stacey Scott led all rookies with 27 points, which ranked eighth overall among all OUA skaters. Katelyn Gosling accumulated 13 points, which finished second among rookie defenders. Her 13 points helped rank her sixth overall among all OUA blueliners in scoring, respectively. 
At the end of the 2011-12 season, Tawn Rellinger and Katie Dillon, both fourth-year players, decided to cut off their hair and donate it to Locks of Love.