"What Difference Does It Make?" is a 1984 single by British band The Smiths. The single version can be found on the band's self-titled debut album The Smiths. A different version recorded for the John Peel Show on BBC Radio One is featured on the compilation album Hatful of Hollow.
Morrissey has stated that "What Difference Does It Make?" is among his least favourite Smiths songs. However, it became one of the band's first significant chart hits, peaking at No. 12 in the UK.
The song is recognised by the opening riff by guitarist Johnny Marr and the falsetto by Morrissey towards the end of the song.
The single cover is a photograph taken on the set of the film The Collector (but not depicted in the actual film), based on the novel by John Fowles. In fact, the title could be a reference to a line from the movie ("What difference does a few specimens make to an entire species"). Originally Terence Stamp denied permission for the still to be used, and some pressings featured lead singer Morrissey in a re-enacted scene. In the re-enactment Morrissey is holding a glass of milk, as opposed to a chloroform pad in the original. Eventually, however, Stamp changed his mind, and the covers featuring Morrissey are now very rare and collectible.
"What Difference Does It Make?" was released without an accompanying music video. Speaking to Tony Fletcher on The Tube in 1984, Morrissey remarked that he felt that the video market was something that was going to "die very quickly", and that he wanted to "herald the death" of it.