In an interview with Hip Hop Canada, Juelz Santana remarked that his approach to the making of "What the Game's Been Missing" was different from his other albums, noting the amount of effort and work he was able to contribute to it, saying:
"I'm definitely going to say that I like this album the best mainly because I got to work on it and I got to grow with it. I took care of a lot of things on it and not to say that my other albums were not good, but I just got to put more work into the making of this one."
Originally 160 songs were recorded for the album, taking over a year to make. He described the process as "learning how to ride a bike." asserting to the fact that the basis of the album developed deeper into production. The album was also influenced by the 1994 film Fresh, In the song "Lil' Boy Fresh" he loosely summarizes the story from beginning to end.
What the Game's Been Missing! peaked at #1 on both the Top Rap Albums and Top R&B/Hip-Hop Albums charts and #9 in the Billboard 200 chart according to Billboard.com. As of September 2006 the album has sold over 655,000 copies.