In 1993, En Vogue covered the song and Salt-n-Pepa rapped over the track. "Whatta Man" is the second single released from Salt-n-Pepa's 1993 album Very Necessary; it was produced by Hurby "Luv Bug" Azor. The song also appeared on En Vogue's Runaway Love EP. "Whatta Man" was a major hit for both Salt-N-Pepa and En Vogue, peaking at number three on the Billboard Hot 100, and at number seven on the UK Singles Chart. It was nominated for the Grammy Award for Best R&B Vocal Performance by a Duo or Group and the American Music Award for Favorite Soul/R&B Single. It was held from reaching #1 by Sheryl Crow's "All I Wanna Do" at 2 and Montell Jordan's "This is How We Do It" at 1.
En Vogue sang the entire vocals on all original and remixed versions of this song. While the song and video features all four members of En Vogue, Cindy Herron does not perform any of the lead vocals. While some lead vocals are performed by Maxine Jones and Terry Ellis, the song is predominantly led by Dawn Robinson.
The 1968 Linda Lyndell/David Crawford version of the song was also covered by German singer Lena Meyer-Landrut as the theme song to the German movie What a Man. It is featured on the Platinum edition her second studio album Good News, it will also feature on the Soundtrack for the movie. It was released on 2 September 2011 as CD single and Digital download in Germany.