Juvenile sampled the Xscape version of the song in 2007 for a song also called "Who Can I Run To?" featuring Mannie Fresh and Soulja Slim. It was on an album entitled "Diary of a Soulja" that was never released. In 1996, Ricky Dillard and the New Generation Chorale released the album, "Worked It Out." It included a version of "Who Can I Run To?" that answered the question with "I need the Lord." 
At the end of 2008, this song was reworked into a house music track with vocals from Dawn Tallman, released on Thick Recordings.