Wikipedia:USEP/Courses/JHU MolBio Ogg FA13/Group 81F

Group 81F

This is a group page for the Johns Hopkins Molecular Biology course. This group will be working on the article TBD.

Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.

Use this page (not the talk page) for article assessments; rationale for selecting an article; etc. (as specified in the milestone summary chart.

Unit 14 Progress Report

• Reworded most of the information on the article to increase general readability.
• Filled out the eukaryotic section to make it easier for lay persons to learn the concepts. Added some corrections to the content.
• Checked grammar and proper wikilinking.
• ...

Unit 12 Progress Report

Allosteric Model added. Illustration pending. Content seems to contain a lot of jargons. Rewording required. RNAi is another way to terminate transcription. Might need to add extra section. History on how transcription termination is elucidated should be added as well.

Unit 10 Progress Report

Eukaryote Torpedo Model added. Allosteric model will be added soon. Pictures to illustrate both model will be needed

Unit 8 Progress Report

1.rho dependent mechanism has started

2.rho independent needs to be added

3. eukaryotic termination needs expansion

4.images needed for all mechanisms.

Gene knockdown

This article was rated stub class. While this article is succinct, it does not contain a lot information about the topic. It would be great if they have a section about gene knockdown and another section about transient knockdown. A side by side table analysis would help displaying the differences. Citing in this article is done sufficiently. I cited another article that could explain how gene knockdown is applicable in cancer research.

Terminator (genetics)

While the table for terminator sequence is helpful, more information on transcription terminator is needed. The mechanism how transcription terminator on gene expression will be a good illustration. This short stub covers both Prokaryotes and Eukaryotes. A different section for each would be a good start to expand this article. I added another article that might clarify poly A in rokaryotes section.

Initial article assessments from Oalnafo1

Restriction site

This article is a stub because although it provides some useful information, it is short, unstructured and not addressed for the general public. In the talk page of the article someone has suggested that the article be integrated into the restriction enzyme article which is much more developed (B-GA grade). I have found a couple references if it is decided that the article will be developed rather than integrated with restriction enzyme.

Viral transformation

This article is a stub because it only includes basic descriptions of the various aspects of the topic and lacks any references. There have been no comments on the talk page. I have found some reviews articles on the topic.

Article selection rationale

We have selected the Terminator (genetics) as our article because it is still very incomplete and our work will be able to greatly increase its value compared to other more developed articles...

Transcription termination is vital to gene expression and protein functions. Unstoppable transcriptions consume rNTPs and affect gene expression of itself and other genes. Without a termination mechanism in place, additional nucleotide would be translated into peptide. The additional of unwanted peptides ultimately distort protein conformation and its functionalities. Loss of functions of cellular proteins is detrimental to cells. This article does not have an expanded explanation on how rho dependent transcription terminators or rho independent transcription terminators ends transcription. It briefly touched on the topic. Additional pictures should be incorporated to illustrate these two mechanisms. In the case of intrinsic transcription terminators, no description of the terminate sequence was shown. A lot more information on prokaryotic and eukaryotic transcription termination can be appended. Transcription termination is an important aspect of the underlying system of gene expression. Our article should be linked to group B’s eukaryotic transcription in my opinion.