Wikipedia:WikiProject Cell Signaling

Key components of the MAPK/ERK pathway, by JWSchmidt.

Some Wikipedians have formed a project to better organize information in articles related to Cell Signaling. This page and its subpages contain their suggestions; it is hoped that this project will help to focus the efforts of other Wikipedians. If you would like to help, please inquire on the talk page and see the to-do list there.

For more information on WikiProjects, please see Wikipedia:WikiProject and Wikipedia:WikiProject/Best practices.

Title

WikiProject on Cell Signaling

Scope

This project is dedicated to improving and organising the Wikipedia articles on cell signaling to provide a convenient and reliable reference of the known signal transduction pathways. It covers the pathway pages and individual protein pages related to them.

Goals

• Creating comprehensive articles for each known cell signaling pathway
• Organising cell signaling articles with navigation boxes like these: Wikipedia:WikiProject Molecular and Cellular Biology#Protein topics navigation boxes.
• Organising and creating articles on notable proteins involved in signaling pathways.
• Providing each pathway with a clear diagram of its structure.
• Clearly citing sources, especially for active research topics

Target audience

• Introduction to pathway articles should make minimal use of jargon and be kept relatively simple
• Subsections and protein pages can be more technical

Parentage

This is a daughter project of WikiProject Molecular and Cellular Biology

Similar WikiProjects

WikiProject Clinical medicine and WikiProject Drugs may be relevant to this project.

Departments

• Wikipedia:WikiProject Cell Signaling/Assessment - the assessment department.

Participants

If you'd like to join the project, please add your name here. If you'd really like to contibute, but don't have much time, you can still participate by adding your name to the Guestlist.

Name	Talk page	Status	Special interests
Rrten00	Talk		EGFR,ErbB2, and MAPK, along with some knowledge of AKT and p53/p21
George Damoulakis	Talk	Casually active	Small G proteins, PI 3-kinase signalling, immunology and neutrophil biology
Peter Znamenskiy	Talk		Cell culture and adult stem cells
F Guesdon	Talk	Casually active	Molecular evolution in the Innate Immune system, particularly TLRs (Toll-like Receptor) and TAK1 (MAP3K7)
Rockpocket	Talk		G-protein coupled receptors
David Iberri	Talk		Embryogenesis (especially nervous system development)
John Schmidt	Talk		illustrations
Gacggt	Talk		Skeletal Muscle biology, Akt pathway, NF-kappaB pathway, some GPCRs, Neurotrophins, MuSK, agrin, Neuromuscular junction, etc
Kohlasz	Talk		Chemotaxis
EquationDoc	Talk		Pathways involved in cancer prevention and formation
JE.at.UWO	Talk		Immunology, development, endocrinology and reproductive physiology.
Biochemza	Talk	Casually active	Immunology, neutrophils, tyrosine kinase signaling, calcium signaling
cyclopamine	Talk	Casually active	Hedgehog pathway, Adult stem cells and cancer
Wisdom89	Talk		Phospholipase, small and large G proteins
David.Throop	Talk		Working on Eicosanoid, Nonclassic eicosanoid and related articles. I am trying to get Eicosanoid up to FA status.
Jmcclare	Talk		Neurochemistry, G proteins, ion channels, pharmacology
Snellios	Talk	Casually active	Knowledgeable on G proteins, ion channels, pharmacology (especially CNS pharmacology), calcium signaling.
ACGGGG	Talk	Casually active	NF-kappaB, MAPKs, innate immunity
Stephen Helms	Talk		G proteins,phospholipase C,protein kinase C,calcium,scaffolding proteins,ion channels, and signaling organization
davebridges	talk	Casually active	G proteins, GAPVD1, protein phosphorylation, pi3p
Subcellular	talk		Ion channels (particularly LGICs), calcium, GPCRs
JustAnotherKinase	talk		[Cell physiology, particularly in immunology and cardiovascular sciences.
Rod57	talk	Casually active	PI3K/AKT/mTOR pathway, Pathways involved in cancer prevention and formation

Guestlist

If you'd really like to contribute, but don't have much time, you can still participate by adding your name to the Guestlist.

Name	Special interests
Tyciol (talk · contribs)	Currently I'm studying biology but don't know enough about cell signaling to be an adequate participant, will once I study it in the future.
Jbarin (talk · contribs)	Immunology, autoimmune disease, T cells, cytokines
Miguel AngeloR (talk · contribs)	Im a student of Celular and Molecular Biology at the New University of Lisbon, I would like to contribute to this page seen as it is the main topic on my course. I so far have complete my Celular biology class in which most of this subject was discussed. I do not know much about how to contribute to wiki and work with other people on the same page, so if would like my help on any subject please contact me and informe about what i need to do. Tanks
Xarus	Undergraduate student of Department of Biology in Yonsei Unv. Also working as a intern student in Glycomics lab. O-GlcNAc, Cell signaling
aqua112233 (talk · contribs)	Immunology, cytokines

Article Structure

Proposed structure of a pathway article:

• General introduction - keep it simple and clear
• History/Discovery - discovery, seminal papers
• Mechanism - the proteins involved and how they interact.
• Role - the role of the pathway
• Human disease - alternatively this can be incorporated into the previous section
• Current research - recent advances, future directions

For individual proteins, see suggestions in Wikipedia:WikiProject_Molecular_and_Cellular_Biology#Structures

Proposed scheme for pathway diagrams is described here. Please do comment and contribute.

Hierarchy definition

No classification of this project has been defined.

Projects

Cell signaling and signal transduction is a very broad field. This section breaks this WikiProject down into smaller, more manageable "mini" projects, with a more specific subject set. Please feel free to add a mini project according to your expertise, or jump in and help on a specific mini project.

• Tyrosine kinase signaling.

Adopt an article

Similar to the Collaboration of the week, but on a smaller scale, you might want to "adopt" an article. This would involve doing the research, writing, and picture-taking (if possible) for either a non-existent article or a stub. Of course, everyone else can still edit an adopted article, and you can work on other things too, but the idea is to find a focus for a while, to try and build up the number of quality articles the Project has produced.

• Example article: User:Example

General strategy and discussion forums

• /General
• /Strategy

Templates

Infoboxes

To do

WikiProject Banners

{{Template:Cell Signaling Project|class=???|importance=???}}

NavBoxes

General

{{Template:Cell_signaling}}

Specific pathways

{{Template:Lipid_signaling}}

{{Template:TGF beta signaling}}

{{Template:Calcium signaling}}

{{Template:MAP kinase activation}}

Signaling molecules

{{Template:Signaling proteins}}

{{Template:Cytokines}}

{{Template:Serine/threonine-specific protein kinases}}

{{Template:Kinases}}

{{Template:Tyrosine kinases}}

{{Template:Protein tyrosine phosphatases}}

Receptors

{{Template:Receptor agonists and antagonists}}

{{Template:T cell receptor}}

{{Template:Growth factor receptors}}

{{Template:Transmembrane receptors}}

{{Template:Tumor necrosis factor receptor superfamily}}

{{Template:Neuropeptide receptors}}

{{Template:G protein-coupled receptors}}

{{Template:Immune receptors}}

{{Template:Chemokine receptors}}

Other molecules

{{Template:Adaptor proteins}}

{{Template:Neurotrophins}}

Articles in Categories

• Category:Signal transduction
• Category:Cell signaling (proposed to be merged with Category:Signal Transduction).

Discussion Archives

• #1

Tools

Wikifying Tools

(From Wikipedia:WikiProject_Wikify)

• Can We Link It? - tool for suggesting and adding possible wiki links to articles. Progressively learns what's a good and a bad link. See here for more info. Also checks for unbalanced wiki syntax, which is sometimes a problem when articles are added by new users.
• The Wikipedia Toolbar for the Firefox web-browser can make editing, formatting and linking much more efficient.
• Also useful is the wikification toolbox containing quick links to Wiki guidelines and handy code snippets

Categorisation tools

(From Wikipedia:WikiProject Categories)

• Category trees – Dumps of the category tree (very handy).
• User:Pearle
• Category Tree and Category Scan

External links

• Wikiproject Watchlist - WikiProject Cell Signaling