Wikipedia talk:Articles for creation/Bioregulatory Medicine

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Bioregulatory Medicine is a postmodern form of integrative medicine that facilitate individual health, by stimulating homeostasis and removing multifactorial aetiologal factors. International Society for Bioregulatory Medicine was founded in 1994 in London, and administer educational programme and board certifies specialist in the field.


In contrast to conventional medicine and its linear cause-effect therapeutic approach, Bioregulatory Medicine approaches multi-factorialism of the biological open systems[1][2]. Bioregulatory Medicine operates along a nonlinear and open flow of bio-information within the human biological system[3], to therapeutically counteract health disruptors and balance physiological network systems[4][5][6][7]. In simple terms, Bioregulatory Medicine facilitates patients’ inherent ability for self-healing (homeostasis).

Although Bioregulatory Medicine builds upon the achievements of evidence-based allopathic medicine, it places medical sciences within the concept of Open Systems Theory[8] and Systems Biology[9]. It incorporates the therapeutic benefits of traditional medicine and newly rising medical approaches, such as Epigenetic theory[10] and psychosomatic medicine[11].

Bioregulatory Medicine offers a fresh view regarding aetiology of diseases, diagnostic criteria and personalisation of medical treatments. To make a medical transition towards systems biology, there is a need for a new Classification of Diseases, which would no longer be based on current fixed diagnostic criteria, but by algorithm of multifactorial nature, specific for every patient.

Currently, the World Health Organization[12] lists diagnosis in decennial publications known as the International Classification of Diseases - (ICD)[13]. The last edition from 1989 (ICD-10)[14] - was delayed for years, since Collaborating Centres for Classification of Diseases were called to come up with new models of alternative structures. The edition in preparation for 2015 or ICD-11 promises to anticipate this need for changes, including the acknowledgment of importance of bioindividuality and physiological network parameters and systems interaction in pathogenesis of diseases.

Bioregulatory Medicine methodology[edit]

Biological Systems Medicine

Although philosophies like Plato’s or Taoism remained outside empiricist-based medical science, both Plato[15] and Lao Tzu[16] laid the foundation for modern systems theory thinkers of 20th century to develop sciences and theories, such as Cybernetics[17]; Epigenetic theory[18], Open Systems Theory[19] and Systems Biology[20]. These feedback-based sciences and theories provided a new scientific platform for the rise of Bioregulatory Medicine.

The characteristic of any system is communication and flow of energy or bits of information, where complex systems are interwoven into larger network systems[21]. Systems-orientated bioregulatory medical treatment is based on the regulation of the informational flow between human biological systems and the external environment.

Elimination of Health Disruptors and Facilitation of Homeostasis

Bioregulatory Medicine aims to identify and counteract health disruptors, such as endocrine disruptors[22], their cumulative toxosynergy; as well as to modulate system networks capable of self-rectifying biochemical errors[23]. It defines a multifaceted and process-oriented therapeutic approach, whose primary objective is to activate or regulate self-corrective homeostatic mechanisms or Homeostasis[24], within their dynamic interplay known as Allostasis[25].

Supporting Eliminatory Pathways and Inflammation

Bioregulatory Medicine introduces a health-centred way of medical thinking that could be practised alongside conventional treatment of pathological manifestations[26]. It therapeutically supports a variety of corrective homeostatic responses, such as eliminatory mechanisms (e.g. sweating or mucous discharge) or inflammation[27]. Scientific research now confirms that therapeutically guided inflammation[28] can be considered as a credible medical treatment, which is gaining in popularity, for example the use of hyperthermia in cancer treatment[29]. This also raises the question over routine suppressions of inflammation by anti-inflammatory drugs in conventional medical practice.

Preventative Health care and Health Economics[edit]

Medicine has always been an art of probability, based on knowledge, experience and the quality of therapeutic communications. It can be argued that allopathic medicine’s emphasis on techno-pharmacology has to some degree divided physicians from their patients, replacing human communication with technical jargon; Bioregulatory medicine puts emphasis back on the humanistic aspect of therapeutic rapport, empowerment of patients and building up health-awareness. Psychological processing becomes the fundamental pillar of patient management, harnessing the potential of positive perception[30][31] to initiate healing. Therapeutic alteration of a patient’s faulty habitual psychological framework is associated with improving neural and informational pathways and networks, and consequent improvement of signal transduction[32]. The experience from bioregulatory clinical practice demonstrates how therapeutic powers of positive perception and the placebo effect[33] are considerably increased when used within the bioregulatory framework, in comparison to their accidental manifestations within a mechanistic model of medicine.

Parameters of Bioregulatory Medicine

Bioregulation of the Biological terrain

The state of one’s health is primarily determined by the quality of the biological terrain[34]; a term usually referring to intercellular living matrix[35]. Its vitality and purity is maintained by the inherent ability of intercellular spaces to swiftly pass nutrients, bioactive molecules and neural impulses to and from cells, and to promptly eliminate metabolic toxicity. This entire informational flow is governed by an inherent intelligence, which manifests itself as dynamic homeostasis[36] or allostasis.[37] Various health disruptors, such as electromagnetic smog, chemical pollution, endocrine disruptors[38], iatrogenically induced toxic pharmacodynamics[39] or prolonged psychological stress may all precipitate pathological changes in the matrix. The toxosynergistic effect of those factors is capable of inducing a chain of pathological reactions within the biological terrain. This process typically involves a build up of toxic waste, disrupting ionic currents, intra and extra cellular changes in concentrations of electrolytes and increases in tissue acidification; which all further precipitates a proliferation of pathological microorganisms. Increased acidity and toxic accumulation create a less-reactive matrix, which block informational flows between neural endings, biological messenger molecules (such as cytokines, neurotransmitters or nitric oxide[40]) and their cellular counterparts. Since a human system operates as an open biological system of informational exchange; bioregulation of non-active biological terrain calls for a multifaceted and process-oriented therapeutic approach to restore its equilibrium[41] . This process may include methods such as: tissue hydration, remineralisation, detoxification, informational reactivation, regulation of tissue pH status and re-colonisation of disturbed microbiome[42]. Since the level of homotoxic exposure cannot be controlled, and scientists cannot accurately predict the long term effects of bioaccumulation in the cells[43] , nor toxic impact of mixing chemicals on human health is fully measurable - medically guided processes of detoxification have become the next logical step forward, towards both preventative and curative therapeutic objectives.[44] Bioregulatory Detoxification

Although the cumulative and synergistic effect of various homotoxins increases entropy[45] and weakens a patient’s constitution, their negative impact on health frequently becomes apparent only after many years. Clinical symptoms of cumulative homotoxicosis may vary, and are often diagnosed as psychosomatic, dysfunctional, iatrogenic or idiopathic conditions. Therapeutically guided bioregulatory detoxification stimulates diffusion of toxins outside the cells and tissues, and facilitates optimal functioning of eliminatory pathways, namely mucocutaneous surfaces (skin and mucous membranes of the respiratory, digestive and uroreproductive systems), hepatobilliary, renal and lymphatic systems. Bioregulatory somatic detoxification also facilitates elimination of homotoxins stored within the extra-cellular matrix, or it may focus on the intracellular level. There is an equal emphasis put on the importance of psychological hygiene for maintenance of health. Its objective is to optimise patients’ cognitive functioning, emotional management and belief systems - by helping them to express their unprocessed emotions, and to let go of negative thoughts and self-limiting beliefs.

Informational Bioregulation

The treatment for bioregulation of the Psychoneuroimmune[46] system and endocrine system, lately frequently referred to as the Psycho-Neuro-Endocrine-Immunological (PNEI) meta-system[47], facilitates informational flow and activates blocked biofeedback (autoregulation) loops. PNEI dysregulation tends to be a multifactorial condition, and requires careful therapeutic assessment, by detection and elimination of a variety of health disruptors to propagation of biological stimuli via hormones, cytokines or neural signalling. Bioregulatory PNEI protocol places emphasis on regulating neural, hormonal and immune network systems by diagnosing and eliminating any noxae (toxins, stress, defficient nutrients..) that has affinity towards imbalance of neuro-endocrine tissues. It also addresses related dietary changes, PNEI specific supplementation of precursors to informational molecules such as homeotherapeutical medication; structural autoregulation (e.g. entrapment neuropathies, perineural congestion, neural osteo-muscular compression). Since emotional factors appear to be a common trigger of PNEI imbalance, for example in the case of increased levels of cortisol and adrenalin, when a person experiences physiological stress - stress management plays a crucial role in PNEI regulation.

Nutritional Bioregulation

A body normally needs regular intakes of over 90 different nutrients to maintain its vitality. If this natural law is not respected, deficiency related symptoms and diseases develop. For example, there are about 150 pathological conditions known to medical science that can be either caused or aggravated by Calcium deficiency alone. Insomnia, muscle cramps and twitches, osteoporosis, hypertension, arthritis, Bell’s palsy, kidney stones, lumbago, colorectal cancer, premenstrual syndrome, gingivitis and receding gums are just a few of them. Since nutritional deficiencies[48] impair homeostatic equilibrium, and free radicals[49] may cause cellular damage, prescribing nutritional supplements is an integral part of bioregulatory medical protocol. Bioregulatory evaluation of nutritional deficiencies, environmental toxicities and oxidative status are based on clinical assessment, laboratory analyses and bioresonance screening. Education on health and a specific dietary guidance are fundamental strategies for nutritional bioregulation. The need for exclusion of acid-forming foods, such as white bread or sugar, in order to prevent acidification of tissues, has already become common knowledge.

Bioregulation of the digestive system may additionally call for a renewal of intestinal mucosa and gut associated lymphatic tissue (GALT)[50]. This recommended therapeutic programme combines specific naturopathic, homeopathic or herbal preparations with a hypoallergenic organic diet and intestinal cleansing. Apart from the use of probiotics, prebiotics, simbiotics,[51] herbal tonics or homeopathic preparations, a complete bioregulatory treatment for the digestive system also incorporates specific bioenergetic, psychosomatic and structural therapeutic support. For example colonic irrigation[52] , lymphatic drainage of cisterna chyli, manual facilitation of peristaltic movements, liberation of entrapped vagal nerve or teaching a patient how to overcome impatience or unprocessed emotions[53] - all tend to optimise the function of the digestive system.

Structural Bioregulation

Since optimal health is associated with locomotor ease and flexibility, structural resistances and rigidities are frequently early signs of declining health. Integrated bioregulatory Psychosomatic Bodywork is used for an assessment and regulation of general somatic restrictions, including fluid stasis or structural resistances of soft and hard tissues. This therapeutic methodology incorporates elements of various massage and bodywork techniques (e.g. physiotherapy, osteopathy, chiropractic, shiatsu, Rolfing, bioenergetics, visceral manipulation, lymphatic drainage massage, biofeedback, craniosacral therapy, polarity therapy and kinesiology) to detect and release structural resistances, such as skeletal misalignments, muscular spasms, fascial restrictions, neural entrapments, restricted mobility of joints, spasms of visceral organs or stagnation of fluid systems. Since structural resistances are frequently a somatic equivalent of unprocessed traumatic experiences, as Dr Wilhelm Reich[54] stated: “...negative attitude toward life acquires a pleasure anxiety, which is physiologically anchored in chronic muscular spasm….”[55] , Psychosomatic Bodywork also supports psychotherapeutic resolutions of unprocessed conflict and traumas.


The immune system is often compromised by silent focal infections, e.g. dental infections. Hypersensitivity reactions like allergic and immunological conditions appear to be the most prevalent in those patients who are already suffering a high toxic load or intestinal Dysbiosis[56]. Bioregulatory treatment for allergic conditions is based on identification of silent foci and allergens, and consequent detoxification, desensitisation and immunomodulation, while strengthening the overall vitality of the biological terrain. Contact with the allergens is avoided for three months, a time during which bioregulatory detoxification can take full effect and remove antibody-antigen complexes[57]. Desensitisation and immunomodulation are facilitated by the use of specific nosodes[58] and homoeopathically prepared immuno-regulatory cytokines[59] [60] [61].

Informational Nanopharmacology

Although Bioregulatory Medicine relies on modern techno-pharmacology, bioregulatory therapeutic interventions are frequently based on the use of specific and homoeopathically prepared medicines, known as homeotherapeuticals[62]. They are combinations of traditional homeopathic remedies and homeopathically prepared immunological preparations, such as hormones, cytokines or micronutrients, which are produced by growing numbers of laboratories worldwide and are classified in the British Homeopathic Formulary.[63]

Bioregulatory Medical treatment

Bioregulatory medical treatment is based on taking a detailed conventional medical history, in addition to psychological evaluation, structural assessment and analysis of nutritional deficiencies, toxicities and patients’ autoregulatory capacities[64]. The essential part of bioregulatory assessment is the identification of factors of health disruption specific for each patient, such as postural, structural, psychological, nutritional or environmental risk factors; where a treatment is then devised to therapeutically counteract their homotoxic impact.

History of the Bioregulatory Medical Approach

Looking into the roots of empirically based contemporary medical science and an epistemology of empiricism itself helps understand conventional medical practice today. Plato[65] for example preferred knowledge based on relations rather then causation, and saw flaws in sensory and causal processings of reality. Aristotle[66]moved away from Plato’s view of the world, and is considered as the founder of empiricism. Even René_Descartes Descartes[67] found empirical views limited, but paradoxically added mechanistic aspects of the human body, which ensured a further reductionism and schism between mind and body - thus enforcing a materialistic view of a ‘human machine’. From this historical point onwards, human sciences became identified almost exclusively by empiricism, which got further determined by Hume[68] and his followers. Since idealism, relativism, vitalism, holism and similar philosophies did not match up to the experimental testing of scientific experimentation, any non-linear approach remained outside medical science. The problem of empiricism in medicine is not with its accuracy, since Newtonian laws[69] proved it beyond any doubt. The issue lies with the inflexibility of empirical laws applied to living systems, which are governed by responsive and adaptive bioregulatory mechanisms capable of orchestrating the healing power of nature. Throughout the history of medicine there were many different medical movements and methodologies fundamentally based on principles of bioregulation. Some of them still survived and continue to exist outside empiricist margins of science. Traditional Chinese Medicine, for example, used acupuncture[70] for thousands of years, to improve the transfer of energy/information, balancing physiological functions[71]. Dr Rudolph Steiner[72] (1861-1925), the founder of Antroposophical[73] medicine, is a typical representative of western medical tradition that is not based on ‘linear science’.

Constantine Hering[74] (1800-1880), a contemporary of the founder of Homoeopathy Dr Samuel Hahnemann[75] (1755-1843), was the first to describe the principles of chronological disease progression, and the steps of its reversal back to health. The principle he described is known in medical history as the Hering’s Law of Cure[76], stating that healing happens from top - down, from inside - out, and in the reverse order of original pathological manifestations[77]. Observing similar predictable reactions and patterns of living biological systems prompted Walter Cannon to introduce in 1932 the concept of Homeostasis into medical world. His concept was later described in more detail by Claude Bernard[78] and his followers, defined as a dynamic and intelligent mechanism of self-regulation and adaptation to changing circumstances of life. Although homeostasis[79] evolved through eons of time from a single cell organisation and more complex systems - towards biological complexity of homo-sapiens, it continues to express the essential bioregulatory nature of all living biological systems. By mid-20st century, many homeostasis [80] based scientific theories started flourishing, including Hans Selye’s[81] General Adaptation Syndrome[82]. Even Norbert Wiener’s[83] theory of Cybernetics[84]sprung as a result of observing homeostasis of living systems, where he described a universal self-regulating principle of homeostasis in living systems as the perfect example of an open system’s feedback.

Following Hering’s and Hahnemann’s homeopathic approach[85] [86] already scientifically widely accepted concept of homeostasis, German physician Dr Hans Henrich Reckeweg (1905-1985) proposed his own bioregulatory medical concept, which he termed Homotoxicology [87] . His concept described disease evolution as a process of progressive homotoxicosis and successively merged homeopathic and allopathic medical doctrines. Reckeweg postulated his 6-phase Vicariation principle, describing how a disease gradually develops along the embryological tissue lineage in three major phases that he described as the humoral, matrix and cellular. Reckeweg’s followers and successors further expanded his concept to Antihomotoxic therapy and Biological Medicine.

Another contemporary of Selye, Weiner and Reckeweg were also Ludvig von Bertalanffy[88] (1901-1972) and Ilya Prigogine[89] (1917 – 2003). Bartalanffy formulated a general systems theory[90], explaining system components and their interaction, he coined the terms ‘open system’ and ‘closed system’; Prigogine wrote about self-organising characteristics of complex biological systems, while their contemporaries and followers further explained complexity, adaptability[91] and related phenomena.

In the mid 1980’s, Dr Damir A Shakambet[92] and Dr Tatyana Bosh[93] started integrating these theories with the intention to bring together conventional medicine and various eastern and western non-allopathic therapeutic methodologies in a common framework, namely bioregulation. The therapeutic shift towards facilitation of homeostatic rebalancing and systems biology was based on the belief that complex diseases need homeostasis-orientated treatment to regulate physiological networks. By the early nineties, the foundations for a coherent, scientifically based and therapeutically effective Bioregulatory System of Health Care had been established, integrating psychotherapy, psychosomatic, nutritional and herbal medicine; as well as various structural, postural and bioenergetic therapies with their allopathic medical knowledge. Dr Shakambet and Dr Bosh found classical homeopathy impossible to integrate within bioregulatory parameters, preferring Dr Reckeweg’s concept of complex homeopathy[94] that was already in ‘alignment’ with allopathic medicine. This integrated medical Meta-system[95] was termed by Dr Shakambet and Dr Bosh as Bioregulatory Medicine.

Bioregulatory Medicine expands the concept of disease evolution further into pathologic morphogenic fields, and places the origin of disease further into quantum, bioresonant and psychosomatic phenomena. Dr Bosh and Dr Shakambet introduced new terminology, such as: ‘Extended Aetiology’, ‘Presomatic Syndrome’ or ‘medically induced spontaneous remission’, which suggest a therapeutic possibility for scientific induction of ‘Restitutio ad Integrum’. Their concept of extended aetiology[96] suggests a new approach to psychosomatic diseases and multifactorial conditions, as well as proposing a medically applicable system of Preventative Healthcare.


Considered Alternative medicine and but since combines medical sciences alike allopathic medicine some find it to be a synthetic approach to medicine by combining artificially two different methodologies.


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