Hart grew up in Ruston, Louisiana, with Bill Doss, Jeff Mangum and Robert Schneider, the founders of the Elephant 6 Recording Company in the early 1990s. Doss and Hart (and even Mangum in its early forms) combined their musical efforts in The Olivia Tremor Control.
Hart and Doss blended their differing musical inclinations for the band: Hart being known as the sonic experimenter, Doss the proponent of pop. This difference is evidently clear in the music produced by each since the end of the Olivia Tremor Control. Hart's Circulatory System maintains an interest in experimentation, while Doss' Sunshine Fix focuses on the simplicity of Beatlesque pop.
Will Cullen Hart is also a visual artist. He has created most, if not all of the artwork for the Olivia Tremor Control and Circulatory System (among other Elephant 6 bands), as well as individual pieces.