Lowe was elected in 1878 as a Greenback to the U.S. House of Representatives, but in initial results was defeated for reelection by Joseph Wheeler in 1880, 601 votes for Lowe having been declared illegal by election judges. In a highly contentious recount that lasted over a year, Lowe successfully contested Wheeler's election and assumed the office on June 3, 1882. Lowe, however, only served four months, and died of tuberculosis at his home in Huntsville on October 12, 1882. He was buried in Maple Hill Cemetery in Huntsville. Wheeler won a special election and served the remaining weeks of the term.