William earned his doctorate from the university in 1931, under W.D. MacMillan. He taught at Pennsylvania State College before joining the United States Naval Observatory in 1936, working under Paul Sollenberger and Gerald Clemence in the time service department.
After having married Rosalyn Shulemson in 1943, Markowitz eventually became director of the department. He developed the ephemeris time scale, which had been adopted by the IAU in 1952 on a proposal formulated by Clemence in 1948, as an international time standard. He subsequently worked with Louis Essen in England to calibrate the newly developed atomic clocks in terms of the ephemeris second. The fundamental frequency of caesium atomic clocks, which they determined as 9,192,631,770 +/- 20 Hz, was used to define the second internationally since 1967. At the International Astronomical Union (IAU) meeting in Dublin in 1955, he had proposed the system of distinguishing between variants of Universal Time, as UT0 (UT as directly observed), UT1 (reduced to invariable meridian by correcting to remove effect of polar motion) and UT2 (further corrected to remove (extrapolated) seasonal variation in earth rotation rate), a system which remains in some use today.
He served as President of the IAU commission on time from 1955 to 1961, and was active in the International Union of Geodesy and Geophysics, the American Geophysical Union, and the International Consultative Committee for the Definition of the Second.
- See references (incl. citations to some of Markowitz's papers) in article Ephemeris time.