Born in Ireland in 1772, Prince immigrated to the United States in 1796 and settled in Indiana. He studied law. He served as Commissioner for Gibson County, Indiana and drew the winning lot to become the county seat's namesake in 1814. Prince served in the Indiana Territorial Council. He then served as territorial auditor. He served in the State senate in 1816. Prince also served as state circuit judge. He served as delegate to the State constitutional convention in 1816. He served as captain in the Battle of Tippecanoe. He served as member of the State house of representatives in 1821 and 1822. He was elected as a Democratic-Republican to the Eighteenth Congress and served from March 4, 1823, until his death near Princeton, Indiana, September 8, 1824. He was interred in the Old Cemetery, near Princeton.