Domain (2002) and Resurrection (2000) by author Steve Alten: A fictional series that tells the events of the Gabriel twins after discovering the mystery behind 2012.
2012: The War for Souls by author Whitley Strieber (2007) is a novel about three parallel earths and the occurrences leading up to December 21, 2012 in each as the walls between them begin to thin and allow passage through gateways to the others. A film adaptation, produced by Michael Bay, was rumoured but has yet to be produced.
The Joshua Files (2008) by M. G. Harris is a series of thrillers for young adults published by Scholastic Children's Books UK, Walker & Company in the US from July 2010. The books feature the adventures of British teenager Josh Garcia who discovers he's linked to an ancient prophecy about the coming events of 2012.
In Jack London's The Scarlet Plague (1912), it is mentioned that Morgan the Fifth was appointed President of The United States by the Board of Magnates in 2012, a year prior to the spread of the Red Death.
In Chuck Barris's The Big Question, the title game show takes place in the year 2012.
JoJo's Bizarre Adventure Part 8: JoJolion (2012–): After the 2011 Tōhoku earthquake and tsunami in the fictional town of Morioh, a young man with the assumed identity of Josuke Higashikata tries to find out who he really is after being found buck naked underground, and with no memory of who he once was, or as he discovers, were.
The final chapter of Tsugumi Ohba's manga Death Note, takes place in January 23, 2012, when the main protagonist is killed by Ryuk after Light Yagami lost in his battle to become God of a new world. Ryuk uses his Death Note to kill Light with a heart attack, which was a part of their original agreement when they met. (2006)
Genesis's song "Get'em Out By Friday" from their 1972 album Foxtrot, sets "18/9/2012" (on the printed operistic-dialog lyrics) as the date when "Genetic Control" would set a height restriction on human beings so that twice as many people could fit on real estate properties.
The Anaal Nathrakh song "Timewave Zero" is about the apparent end of the world on December 21, 2012. The lyrics are translated as "The 21st Of December, 2012, The time will come."
Melodic death metal band Scar Symmetry have referenced 2012 in two songs. First being The song "2012 — Demise of the 5th Sun" from the album Symmetric in Design (2004) with the lyrics: For the lines on the fractal wave / Fit the course of history / They're created to work as one till the end / When the winter solstice comes / Actualizing the prophecy / The demise in 2012 realized" and the song "Radiant Strain'" from the album Dark Matter Dimensions (2009) with the lyrics: 2012, now we all see what it holds.
The Testament song "3 Days in Darkness", off of The Gathering album is a song about 2012, and speaks of the earth being swallowed in molten fire.
VNV Nation's album Praise the Fallen" has the subtitle "PTF 2012", which is also the name of a track in the album, which seems to be predominantly about an upcoming war. The song, "Honour" starts with the line, "Passive fields, January 2012..."
Heavy metal band Burnt By The Sun's two albums both deal with prophecies concerning the year 2012.
One of the puzzles later on in La Mulana (A freeware PC game based on many of the older MSX games released) states you need to 'walk the end year of the Aztec's Fifth Age.' The player must then light only the torches of the gates that correspond to the numbers in the year '2012'.
In Persona 4, which is set in 2011, the characters fight to prevent catastrophe from striking the world at the end of the year. In addition, the game ends in the year 2012 no matter which story ending you get.
The Assassin's Creed series modern-day story is set in 2012, and deals with the eponymous Order's attempts to prevent a predicted cataclysm on December 21, 2012.
The game Oni briefly mentions a series of 'Freedom Riots' that occurred in 2012.
According to the front cover of the game, Road Trip Adventure is set in September of this year.