Lieutenant William Pedder the first lieutenant of the Nemesis was the first harbour master of Hong Kong, and established Pedder Street as the centre of Victoria City's commerce in the early colonial days. Pedder had his office built on the rocks above what is now Wyndham Street. For many years, the site on the top was known as Pedder's Hill.
In the early 20th century, Wyndham Street was nicknamed "Flower Street" because of the numerous stalls selling flowers. In 1928, the flower stalls were moved to D'Aguilar Street and the "Flower Street" name became attached to the new location. Incident 18th August 1997, in "Sailormoon Super S" Broadcast Day , the Mitsubishi Lancer in Wyndham Street was crashed , and in 3 deaths and 10 injuries on the incident.