Wyoming Highway 215 begins at I-80 Business/US 30 (Parson Street) just north of exit 401 of I-80/US 30 in Pine Bluffs. WYO 215 travels west, crossing Old U.S. 30, as it begins to turn north on the western edge of Pine Bluffs. Named Pine Bluffs-Albin Road, WYO 215 stays due north for the greater part of its routing. At 17.19 miles (27.66 km), Highway 215 reaches its northern terminus at Wyoming Highway 216 near Albin. North of Albin, the roadway continues north as Laramie County Route 162-2 north to Wyoming Highway 151 near LaGrange.