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XIAP associated factor 1
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606717 MGI3505735 HomoloGene49488 GeneCards: XAF1 Gene
RNA expression pattern
PBB GE XAF1 206133 at tn.png
More reference expression data
Species Human Mouse
Entrez 54739 327959
Ensembl ENSG00000132530 ENSMUSG00000040483
UniProt Q6GPH4 Q5NBU8
RefSeq (mRNA) NM_017523 NM_001037713
RefSeq (protein) NP_059993 NP_001032802
Location (UCSC) Chr 17:
6.66 – 6.68 Mb
Chr 11:
72.3 – 72.31 Mb
PubMed search [1] [2]

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.[1][2][3]


X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001).[supplied by OMIM][3]


XAF1 has been shown to interact with XIAP.[2]


  1. ^ Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S et al. (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096. 
  2. ^ a b Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D et al. (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. 
  3. ^ a b "Entrez Gene: XAF1 XIAP associated factor-1". 

Further reading[edit]

  • Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG (2000). "Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines". Genomics 70 (1): 113–22. doi:10.1006/geno.2000.6364. PMID 11087668. 
  • Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411. 
  • Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR et al. (2003). "Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas". Cancer Res. 63 (21): 7068–75. PMID 14612497. 
  • Ng KC, Campos EI, Martinka M, Li G (2004). "XAF1 expression is significantly reduced in human melanoma". J. Invest. Dermatol. 123 (6): 1127–34. doi:10.1111/j.0022-202X.2004.23467.x. PMID 15610524. 
  • Wang J, He H, Yu L, Xia HH, Lin MC, Gu Q et al. (2006). "HSF1 down-regulates XAF1 through transcriptional regulation". J. Biol. Chem. 281 (5): 2451–9. doi:10.1074/jbc.M505890200. PMID 16303760. 
  • Yin W, Cheepala S, Clifford JL (2006). "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1". Biochem. Biophys. Res. Commun. 339 (4): 1148–54. doi:10.1016/j.bbrc.2005.11.128. PMID 16343440. 
  • Fang X, Liu Z, Fan Y, Zheng C, Nilson S, Egevad L et al. (2006). "Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor". Int. J. Cancer 118 (10): 2485–9. doi:10.1002/ijc.21636. PMID 16353137. 
  • Gilli F, Marnetto F, Caldano M, Sala A, Malucchi S, Capobianco M et al. (2006). "Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1". Mult. Scler. 12 (1): 47–57. doi:10.1191/135248506ms1245oa. PMID 16459719. 
  • Reu FJ, Bae SI, Cherkassky L, Leaman DW, Lindner D, Beaulieu N et al. (2006). "Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation". J. Clin. Oncol. 24 (23): 3771–9. doi:10.1200/JCO.2005.03.4074. PMID 16801630. 
  • Lee MG, Huh JS, Chung SK, Lee JH, Byun DS, Ryu BK et al. (2006). "Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses". Oncogene 25 (42): 5807–22. doi:10.1038/sj.onc.1209867. PMID 16909101. 
  • Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP et al. (2006). "Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers". Gastroenterology 131 (6): 1835–43. doi:10.1053/j.gastro.2006.09.050. PMID 17087954. 
  • Micali OC, Cheung HH, Plenchette S, Hurley SL, Liston P, LaCasse EC et al. (2007). "Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta". BMC Cancer 7: 52. doi:10.1186/1471-2407-7-52. PMC 1845166. PMID 17376236. 
  • Kempkensteffen C, Hinz S, Schrader M, Christoph F, Magheli A, Krause H et al. (2007). "Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome". Cancer Lett. 254 (2): 227–35. doi:10.1016/j.canlet.2007.03.006. PMID 17449173. 
  • Shibata T, Mahotka C, Wethkamp N, Heikaus S, Gabbert HE, Ramp U (2007). "Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas". Diagn. Mol. Pathol. 16 (1): 1–8. doi:10.1097/01.pdm.0000213471.92925.51. PMID 17471152. 
  • Chung SK, Lee MG, Ryu BK, Lee JH, Han J, Byun DS et al. (2007). "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses". Gastroenterology 132 (7): 2459–77. doi:10.1053/j.gastro.2007.04.024. PMID 17570219. 
  • Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG (2007). "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex". J. Biol. Chem. 282 (36): 26202–9. doi:10.1074/jbc.M700776200. PMID 17613533.