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XIAP associated factor 1
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606717 MGI3505735 HomoloGene49488 GeneCards: XAF1 Gene
RNA expression pattern
PBB GE XAF1 206133 at tn.png
More reference expression data
Species Human Mouse
Entrez 54739 327959
Ensembl ENSG00000132530 ENSMUSG00000040483
UniProt Q6GPH4 Q5NBU8
RefSeq (mRNA) NM_017523 NM_001037713
RefSeq (protein) NP_059993 NP_001032802
Location (UCSC) Chr 17:
6.66 – 6.68 Mb
Chr 11:
72.3 – 72.31 Mb
PubMed search [1] [2]

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.[1][2][3]

X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001).[supplied by OMIM][3]


XAF1 has been shown to interact with XIAP.[2]


  1. ^ Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J Biol Chem 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096. 
  2. ^ a b Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat Cell Biol 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. 
  3. ^ a b "Entrez Gene: XAF1 XIAP associated factor-1". 

Further reading[edit]