XCL1

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chemokine (C motif) ligand 1, lymphotactin
Identifiers
Symbol XCL1
Alt. symbols SCYC1, LTN, LPTN, ATAC, SCM-1a, SCM-1
Entrez 6375
HUGO 10645
OMIM 600250
RefSeq NM_002995
UniProt P47992
Other data
Locus Chr. 1 q24.2

Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells.[1][2] This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose gene is found at the same locus on chromosome 1.[2] XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.[3]

Lymphotactin, LTN, is found in two states: a monomer at 10°C, LTN10, and a dimer at 40°C, LTN40.[4]

References[edit]

  1. ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol 155 (1): 203–9. PMID 7602097. 
  2. ^ a b Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694. 
  3. ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725. 
  4. ^ Tyler, Robert C.; Tyler, R. C.; Murray, N. J.; Peterson, F. C.; Volkman, B. F. (2011). "Native state interconversion of a metamorphic protein requires global unfolding". Biochemistry 50 (33): 7077–9. doi:10.1021/bi200750k. PMC 3160782. PMID 21776971.