XCR1

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Chemokine (C motif) receptor 1
Identifiers
Symbols XCR1 ; CCXCR1; GPR5
External IDs OMIM600552 MGI1346338 HomoloGene21095 IUPHAR: XCR1 ChEMBL: 4339 GeneCards: XCR1 Gene
RNA expression pattern
PBB GE XCR1 221468 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2829 23832
Ensembl ENSG00000173578 ENSMUSG00000060509
UniProt P46094 Q9R0M1
RefSeq (mRNA) NM_001024644 NM_011798
RefSeq (protein) NP_001019815 NP_035928
Location (UCSC) Chr 3:
46.06 – 46.07 Mb
Chr 9:
123.85 – 123.86 Mb
PubMed search [1] [2]

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

References[edit]

External links[edit]

  • "Chemokine Receptors: XCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.