CKAP5

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Cytoskeleton associated protein 5
Identifiers
Symbols CKAP5 ; CHTOG; MSPS; TOG; TOGp; ch-TOG
External IDs OMIM611142 MGI1923036 HomoloGene8844 GeneCards: CKAP5 Gene
RNA expression pattern
PBB GE CKAP5 212832 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9793 75786
Ensembl ENSG00000175216 ENSMUSG00000040549
UniProt Q14008 A2AGT5
RefSeq (mRNA) NM_001008938 NM_001165989
RefSeq (protein) NP_001008938 NP_001159461
Location (UCSC) Chr 11:
46.76 – 46.87 Mb
Chr 2:
91.53 – 91.62 Mb
PubMed search [1] [2]

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene.[1][2][3] It is the homolog of the Xenopus protein XMAP215[4] and is also known as ch-Tog.

It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.[5]


Interactions[edit]

CKAP5 has been shown to interact with TACC1.[6][7]

References[edit]

  1. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527. 
  2. ^ Charrasse S, Mazel M, Taviaux S, Berta P, Chow T, Larroque C (Feb 1996). "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur J Biochem 234 (2): 406–13. doi:10.1111/j.1432-1033.1995.406_b.x. PMID 8536682. 
  3. ^ "Entrez Gene: CKAP5 cytoskeleton associated protein 5". 
  4. ^ Cassimeris, L.; Morabito, J. (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Molecular Biology of the Cell 15 (4): 1580–1590. doi:10.1091/mbc.E03-07-0544. PMC 379257. PMID 14718566.  edit
  5. ^ Barr, A.; Gergely, F. (2008). "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Molecular and Cellular Biology 28 (23): 7199–7211. doi:10.1128/MCB.01040-08. PMC 2593372. PMID 18809577.  edit
  6. ^ Conte, Nathalie; Delaval Bénédicte; Ginestier Christophe; Ferrand Alexia; Isnardon Daniel; Larroque Christian; Prigent Claude; Séraphin Bertrand; Jacquemier Jocelyne; Birnbaum Daniel (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene (England) 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. ISSN 0950-9232. PMID 14603251. 
  7. ^ Lauffart, Brenda; Howell Scott J; Tasch Jason E; Cowell John K; Still Ivan H (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. (England) 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. ISSN 0264-6021. PMC 1222467. PMID 11903063. 

Further reading[edit]