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Xeroderma pigmentosum, complementation group A
Protein XPA PDB 1d4u.png
PDB rendering based on 1d4u.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols XPA ; XP1; XPAC
External IDs OMIM611153 MGI99135 HomoloGene37298 GeneCards: XPA Gene
RNA expression pattern
PBB GE XPA 205672 at tn.png
More reference expression data
Species Human Mouse
Entrez 7507 22590
Ensembl ENSG00000136936 ENSMUSG00000028329
UniProt P23025 Q64267
RefSeq (mRNA) NM_000380 NM_011728
RefSeq (protein) NP_000371 NP_035858
Location (UCSC) Chr 9:
100.44 – 100.46 Mb
Chr 4:
46.16 – 46.2 Mb
PubMed search [1] [2]

DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.[1]


XPA has been shown to interact with ERCC1,[2][3] Replication protein A1[4] and XAB2.[5]


  1. ^ "Entrez Gene: XPA xeroderma pigmentosum, complementation group A". 
  2. ^ Li, L; Elledge S J; Peterson C A; Bales E S; Legerski R J (May 1994). "Specific association between the human DNA repair proteins XPA and ERCC1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (11): 5012–6. doi:10.1073/pnas.91.11.5012. ISSN 0027-8424. PMC 43920. PMID 8197174. 
  3. ^ Nagai, A; Saijo M; Kuraoka I; Matsuda T; Kodo N; Nakatsu Y; Mimaki T; Mino M; Biggerstaff M; Wood R D (June 1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochem. Biophys. Res. Commun. (UNITED STATES) 211 (3): 960–6. doi:10.1006/bbrc.1995.1905. ISSN 0006-291X. PMID 7598728. 
  4. ^ Li, L; Lu X; Peterson C A; Legerski R J (October 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690. 
  5. ^ Nakatsu, Y; Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo J P, Khaw M C, Saijo M, Kodo N, Matsuda T, Hoeijmakers J H, Tanaka K (November 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. (UNITED STATES) 275 (45): 34931–7. doi:10.1074/jbc.M004936200. ISSN 0021-9258. PMID 10944529. 

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