XPA

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Xeroderma pigmentosum, complementation group A
Protein XPA PDB 1d4u.png
PDB rendering based on 1d4u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols XPA ; XP1; XPAC
External IDs OMIM611153 MGI99135 HomoloGene37298 GeneCards: XPA Gene
RNA expression pattern
PBB GE XPA 205672 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7507 22590
Ensembl ENSG00000136936 ENSMUSG00000028329
UniProt P23025 Q64267
RefSeq (mRNA) NM_000380 NM_011728
RefSeq (protein) NP_000371 NP_035858
Location (UCSC) Chr 9:
100.44 – 100.46 Mb
Chr 4:
46.16 – 46.2 Mb
PubMed search [1] [2]

DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.[1]


Interactions[edit]

XPA has been shown to interact with ERCC1,[2][3] Replication protein A1[4] and XAB2.[5]

References[edit]

  1. ^ "Entrez Gene: XPA xeroderma pigmentosum, complementation group A". 
  2. ^ Li, L; Elledge S J; Peterson C A; Bales E S; Legerski R J (May 1994). "Specific association between the human DNA repair proteins XPA and ERCC1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (11): 5012–6. doi:10.1073/pnas.91.11.5012. ISSN 0027-8424. PMC 43920. PMID 8197174. 
  3. ^ Nagai, A; Saijo M; Kuraoka I; Matsuda T; Kodo N; Nakatsu Y; Mimaki T; Mino M; Biggerstaff M; Wood R D (June 1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochem. Biophys. Res. Commun. (UNITED STATES) 211 (3): 960–6. doi:10.1006/bbrc.1995.1905. ISSN 0006-291X. PMID 7598728. 
  4. ^ Li, L; Lu X; Peterson C A; Legerski R J (October 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690. 
  5. ^ Nakatsu, Y; Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo J P, Khaw M C, Saijo M, Kodo N, Matsuda T, Hoeijmakers J H, Tanaka K (November 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. (UNITED STATES) 275 (45): 34931–7. doi:10.1074/jbc.M004936200. ISSN 0021-9258. PMID 10944529. 

Further reading[edit]

External links[edit]