DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.[1]
[edit] Interactions
XPA has been shown to interact with ERCC1,[2][3] Replication protein A1[4] and XAB2.[5]
[edit] References
- ^ "Entrez Gene: XPA xeroderma pigmentosum, complementation group A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7507.
- ^ Li, L; Elledge S J, Peterson C A, Bales E S, Legerski R J (May. 1994). "Specific association between the human DNA repair proteins XPA and ERCC1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (11): 5012–6. doi:10.1073/pnas.91.11.5012. ISSN 0027-8424. PMC 43920. PMID 8197174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43920.
- ^ Nagai, A; Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, Mimaki T, Mino M, Biggerstaff M, Wood R D (Jun. 1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochem. Biophys. Res. Commun. (UNITED STATES) 211 (3): 960–6. doi:10.1006/bbrc.1995.1905. ISSN 0006-291X. PMID 7598728.
- ^ Li, L; Lu X, Peterson C A, Legerski R J (Oct. 1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. (UNITED STATES) 15 (10): 5396–402. ISSN 0270-7306. PMC 230789. PMID 7565690. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230789.
- ^ Nakatsu, Y; Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo J P, Khaw M C, Saijo M, Kodo N, Matsuda T, Hoeijmakers J H, Tanaka K (Nov. 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. (UNITED STATES) 275 (45): 34931–7. doi:10.1074/jbc.M004936200. ISSN 0021-9258. PMID 10944529.
[edit] Further reading
- Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy". Hum. Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
- Morikawa K, Shirakawa M (2000). "Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA". Mutat. Res. 460 (3–4): 257–75. PMID 10946233.
- Satokata I, Tanaka K, Okada Y (1992). "Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene". Hum. Genet. 88 (6): 603–7. doi:10.1007/BF02265282. PMID 1339397.
- Satokata I, Tanaka K, Yuba S, Okada Y (1992). "Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum". Mutat. Res. 273 (2): 203–12. PMID 1372103.
- Miyamoto I, Miura N, Niwa H et al (1992). "Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair". J. Biol. Chem. 267 (17): 12182–7. PMID 1601884.
- Satokata I, Tanaka K, Miura N et al (1991). "Characterization of a splicing mutation in group A xeroderma pigmentosum". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9908–12. doi:10.1073/pnas.87.24.9908. PMC 55283. PMID 1702221. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55283.
- Miura N, Miyamoto I, Asahina H et al (1991). "Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene". J. Biol. Chem. 266 (29): 19786–9. PMID 1918083.
- Tanaka K, Miura N, Satokata I et al (1990). "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain". Nature 348 (6296): 73–6. doi:10.1038/348073a0. PMID 2234061.
- Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. PMC 230789. PMID 7565690. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230789.
- Nagai A, Saijo M, Kuraoka I et al (1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein". Biochem. Biophys. Res. Commun. 211 (3): 960–6. doi:10.1006/bbrc.1995.1905. PMID 7598728.
- Farndon PA, Morris DJ, Hardy C et al (1995). "Analysis of 133 meioses places the genes for nevoid basal cell carcinoma (Gorlin) syndrome and Fanconi anemia group C in a 2.6-cM interval and contributes to the fine map of 9q22.3". Genomics 23 (2): 486–9. doi:10.1006/geno.1994.1528. PMID 7835901.
- Park CH, Mu D, Reardon JT, Sancar A (1995). "The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor". J. Biol. Chem. 270 (9): 4896–902. doi:10.1074/jbc.270.9.4896. PMID 7876263.
- Li L, Elledge SJ, Peterson CA et al (1994). "Specific association between the human DNA repair proteins XPA and ERCC1". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5012–6. doi:10.1073/pnas.91.11.5012. PMC 43920. PMID 8197174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43920.
- Park CH, Sancar A (1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5017–21. doi:10.1073/pnas.91.11.5017. PMC 43921. PMID 8197175. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43921.
- Satokata I, Iwai K, Matsuda T et al (1994). "Genomic characterization of the human DNA excision repair-controlling gene XPAC". Gene 136 (1–2): 345–8. doi:10.1016/0378-1119(93)90493-M. PMID 8294029.
- Tanaka K (1993). "The Japan Society of Human Genetics Award Lecture. Molecular analysis of xeroderma pigmentosum group A gene". Jpn. J. Hum. Genet. 38 (1): 1–14. doi:10.1007/BF01891230. PMID 8504220.
- Topping RS, Myrand SP, Williams BL et al (1996). "Characterization of the human XPA promoter". Gene 166 (2): 341–2. doi:10.1016/0378-1119(95)00649-4. PMID 8543191.
- Lench NJ, Telford EA, Andersen SE et al (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
- Selby CP, Sancar A (1997). "Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II". J. Biol. Chem. 272 (3): 1885–90. doi:10.1074/jbc.272.3.1885. PMID 8999876.
- Hayashi T, Takao M, Tanaka K, Yasui A (1998). "ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines". Mutat. Res. 407 (3): 269–76. PMID 9653453.
[edit] External links
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PDB gallery
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1d4u: INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIR PROTEIN XPA WITH RPA70 AND DNA: CHEMICAL SHIFT MAPPING AND 15N NMR RELAXATION STUDIES
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1xpa: SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
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| Excision repair |
Base excision repair/ AP site ( DNA glycosylase, Uracil-DNA glycosylase, Poly ADP ribose polymerase) • Nucleotide excision repair/ ERCC ( XPA, XPB, XPC, XPD/ERCC2, XPE/DDB1, XPF/DDB1, XPG/ERCC5, ERCC1, RPA, RAD23A, RAD23B, Excinuclease)
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| Other forms of repair |
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| Other/ungrouped proteins |
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| Regulation |
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| Other/ungrouped |
8-Oxoguanine • Adaptive response • Meiotic recombination checkpoint • RecF pathway
DNA helicase: BLM · WRN
FANC proteins: core protein complex ( FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM), FANCD1, FANCD2, FANCI, FANCJ, FANCN
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see also DNA repair-deficiency disorder
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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