From Wikipedia, the free encyclopedia
Jump to: navigation, search
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
External IDs OMIM300145 MGI2180001 HomoloGene37766 ChEMBL: 4610 GeneCards: XPNPEP2 Gene
EC number
RNA expression pattern
PBB GE XPNPEP2 216910 at tn.png
PBB GE XPNPEP2 206484 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7512 170745
Ensembl ENSG00000122121 ENSMUSG00000037005
UniProt O43895 B1AVD1
RefSeq (mRNA) NM_003399 NM_001289729
RefSeq (protein) NP_003390 NP_001276658
Location (UCSC) Chr X:
129.74 – 129.77 Mb
Chr X:
48.11 – 48.14 Mb
PubMed search [1] [2]

Xaa-Pro aminopeptidase 2 is an enzyme that in humans is encoded by the XPNPEP2 gene.[1][2][3]

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.[3]


  1. ^ Venema RC, Ju H, Zou R, Venema VJ, Ryan JW (Dec 1997). "Cloning and tissue distribution of human membrane-bound aminopeptidase P". Biochim Biophys Acta 1354 (1): 45–8. doi:10.1016/s0167-4781(97)00126-7. PMID 9375790. 
  2. ^ Sprinkle TJ, Stone AA, Venema RC, Denslow ND, Caldwell C, Ryan JW (Apr 1999). "Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25". Genomics 50 (1): 114–6. doi:10.1006/geno.1998.5302. PMID 9628831. 
  3. ^ a b "Entrez Gene: XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound". 

Further reading[edit]